If it does not mention hyperforin, I would look for a different source. activities are attributable to hypericin and hyperforin [26]. Also, hyperforin is not very stable when exposed to oxygen. St. John's wort is often used to treat depression and menopausal symptoms. There are no human studies that show the same effect, so I decided not to worry about it. It's worth a try. JUMP TO #1 ST. JOHN’S WORT SUPPLEMENT. That is half of the reason I recommend Perika brand. Hyperforin is one constituent of SJW that alters CYP3A4 expression by activation of the nuclear receptor pregnane X receptor (PXR). SJW up-regulates serotonin receptors and also has a significant . The herbal remedy St. John’s wort (SJW) is used in the treatment of mild depressive symptoms and is known for its drug-drug interaction potential when enhanced expression of CYP3A4 modifies clearance of concomitantly applied substrate drugs. In vitro, it acted as a reuptake inhibitor of monoamines (MRI), including serotonin, norepinephrine, dopamine, and of GABA and glutamate, with IC 50 values of 0.05-0.10 μg/mL for all compounds, with the exception of glutamate, which is in the 0.5 μg/mL range. Initially, Hypericin, a napthodianthrone compound was considered to be the anti depressant principle of the herb, but now it is better known as marker compound in Hypericum perforatum extract and is used as identification standard in Hypericum samples. Evidence. I've seen statistics that Germany treats HALF of their cases of depression with it. I started taking 2 g of EPA a day. I started taking Vit D. I started taking St John's Wort, one with a guarantee of 2-4% hyperforin content (thought to be the active component). Also, this herb has numerous upregulating effects on liver enzymes which will affect the metabolism of other drugs/supplements. The flowers and leaves of St. John's wort contain active ingredients such as hyperforin. Hyperforin, hypericin, and the flavonoid I3,II8‐biapigenin showed a clear inhibition of enzyme preparations in vitro; 43 however, no effect of hyperforin and hypericin on CYP2D6 activity was seen in primary human hepatocytes. Amentoflavone was shown to be potent inhibitor of CYP3A4, CYP1A2 and CYP2C9. 97 ($0.12/Count) They stabilize the extract, so that it lasts more than a couple weeks. Clinical studies show hyperforin to inhibit the neural uptake of serotonin, norepinephrine, and dopamine. 3 Must See Warnings: There are some animal studies that show Hyperforin/hypericin to cause cataracts. Remember, outside of America, this stuff is prescribed to many folks. Hyperforin was shown as potent non-competitive inhibitor of CYP2C9, CYP2D6 and CYP3A4. 2% hyperforin is what you are looking for. The other active compound that warrants discussion is hypericin. 1,000mg Ultra High Strength St. John's Wort Capsules (Non-GMO) - 7X Concentrated Extract - The Strongest St Johns Wort Capsules Available - 0.3% Hypericin - 120 Capsules 4.6 out of 5 stars 1,445 $13.97 $ 13 . Most of this herb's pharmacological activities are attributable to hypericin and hyperforin [26]. SJW up-regulates serotonin receptors and also has a significant affinity for opiate sigma receptors, which may contribute to its antidepressant effect [27]. Hyperforin may be a constituent responsible for the antidepressant and anxiolytic properties of the extracts of St. John's wort. Hyperforin, amentoflavone, hypericin, quercetrin and chlorogenic acid, all demonstrated inhibitory affect on cytochrome P450 (CYP) enzyme activities. Along with its antidepressant activity, hyperforin also has anxiolytic, antioxidant, and anti-inflammatory effects. 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